Mechanisms of antibiotic resistance
| | Gm +ive | Gm-ive | ||||
| | Intracellular accumulation of drug | Alteration in target | Drug inactivating enzymes | Intracellular accumulation of drug | Alteration in target | Drug inactivating enzymes |
| Beta lactam | - | + | ++ | + | ± | +++ |
| Aminoglycosides | + | ± | +++ | + | ± | +++ |
| Fluoroquinolones | + | +++ | - | + | +++ | - |
| Rifampin | - | +++ | - | - | +++ | - |
| Tetracyclines | +++ | ± | - | +++ | ± | - |
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