unconjugated bilirubin
§ not soluble in water
§ bound to albumin
§ not excreted in urine
§ crosses BBB
§ can cause kernicterus
§ Reacts more slowly. Still produces azobilirubin. Ethanol makes all bilirubin react promptly then calc: Indirect bilirubin = Total bilirubin - Direct bilirubin
Conjugated biliurbin
§ Soluble in water
§ Excreted in urine as urobilinogen
§ Bound to glucuronic acid
§ Reacts quickly when dyes (diazo reagent) are added to the blood specimen to produce azobilirubin "Direct bilirubin"
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